GeneXpert—A Game-Changer for Tuberculosis Control?
نویسنده
چکیده
Tuberculosis (TB) kills more people than any other single infection, the global burden of TB cases and drug resistance are increasing [1], and most patients still only have access to an inadequate diagnostic test developed more than a century ago. Recent evaluations of a desktop machine called the GeneXpert MTB/ RIF that in less than two hours simultaneously detects Mycobacterium tuberculosis and tests for drug resistance have stimulated tremendous enthusiasm [2,3]. Is this the breakthrough that TB control has been waiting for?
منابع مشابه
GeneXpert TB 8: A point-of-care diagnostic pilot.
524 August 2014, Vol. 104, No. 8 GeneXpert TB 8: A point-of-care diagnostic pilot To the Editor: The point-of-care (POC) GeneXpert MTB/RIF detects Mycobacterium tuberculosis (MTB) and drug resistance in under 2 hours and was hailed a ‘game-changer’ for tuberculosis (TB) control.[1] Recent results from Evaluating a New Diagnostic Trial (EXTEND) show that while implementing the GeneXpert had more...
متن کاملInitial experience with GeneXpert MTB/RIF assay in the Arkansas Tuberculosis Control Program.
BACKGROUND Mycobacterium tuberculosis remains one of the most significant causes of death from an infectious agent. Rapid and accurate diagnosis of pulmonary and extra-pulmonary tuberculosis (TB) is still a great challenge. The GeneXpert MTB/RIF assay is a novel integrated diagnostic system for the diagnosis of tuberculosis and rapid detection of Rifampin (RIF) resistance in clinical specimens....
متن کاملEvaluation of GeneXpert MTB/RIF for determination of rifampicin resistance among new tuberculosis cases in west and northwest Iran
Despite a Mycobacterium tuberculosis control programme and anti-tuberculosis drugs, drug-resistant tuberculosis (DR-TB) is one of the most serious public health issues worldwide. Rapid laboratory diagnosis of M. tuberculosis is needed for the diagnosis of multidrug-resistant (MDR) TB and to find the optimal treatment protocol. The purpose of this study was to detect resistance to rifampicin in ...
متن کاملTuberculosis diagnosis in resource-limited settings: Clinical use of GeneXpert in the diagnosis of smear-negative PTB: a case report.
BACKGROUND The Xpert MTB/RIF test (GeneXpert) has recently been endorsed for use in resource-limited settings for the diagnosis of tuberculosis and drug resistant-tuberculosis. In resource-limited settings, GeneXpert has been used predominantly for research and there is little experience with its use in day-to-day management of patients. CASE SUMMARY We describe a case of a 46 year old HIV-in...
متن کاملGeneXpert MTB/RIF Testing in the Management of Patients with Active Tuberculosis; A Real Life Experience from Saudi Arabia
BACKGROUND GeneXpert MTB/RIF is a real-time PCR assay with established diagnostic performance in pulmonary and extra-pulmonary forms of tuberculosis. The aim of this study was to assess the contribution of GeneXpert MTB/RIF assay to the management of patients with any form of active tuberculosis in a single large tertiary center in Saudi Arabia, with a special focus on the impact on time to sta...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2011